WEBVTT

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These instructions for use are applicable for the 45 mg
and the 90 mg pre-filled syringe.

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There is no difference regarding the handling of
the pre-filled syringe between the two strengths.

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Welcome to this guide,

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which sets out the correct use of the
UZPRUVO single-use pre-filled syringe.

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The syringe is made up of four parts:
needle cover,

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needle, syringe body and plunger.

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Let's see how it works.

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UZPRUVO should
be stored in a refrigerator

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at a temperature
of 2 to 8°C.

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Do not freeze UZPRUVO.

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Keep pre-filled syringes in the outer carton

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in order to protect from light.

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If needed, individual pre-filled syringes
may be stored at room temperature

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up to 30°C for a maximum
single period of up to 30 days

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without exceeding the original
expiry date.

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First,
take UZPRUVO out of the refrigerator.

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Before administration,
UZPRUVO should be allowed

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to reach room temperature

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(allow approximately half an hour).

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The UZPRUVO pre-filled
syringe is for subcutaneous use only.

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Do not mix UZPRUVO
with other liquids for injection

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and do not shake UZPRUVO
pre-filled syringes.

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Remove the outer carton.

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Check to make sure
you have the correct dose.

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Ensure the pre-filled syringe
has not passed its expiry date

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by checking the expiry date on the label.

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Make sure that the solution
in the pre-filled syringe is clear

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and colourless to slightly yellow
and practically free of visible particles.

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Do not use if the product has expired,
or if the solution appears

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discoloured or cloudy,
or contains large particles.

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Lay out everything you will need
on a clean surface:

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your prescribed dose of UZPRUVO,
an antiseptic wipe, a cotton ball or gauze pad,

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an adhesive bandage

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and a puncture resistant sharps
disposal container.

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Do not use
if the pre-filled syringe is damaged,

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or if the solution in the
pre-filled syringe is frozen.

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Wash your hands

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very well with soap and warm water.

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Begin by choosing an injection site.

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Good places
for the injection are around the belly,

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at least five centimeters
away from the navel,

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the upper thigh or buttocks.

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Use a different injection
site for each injection.

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Clean the skin with the antiseptic wipe
where you plan to give your injection.

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Let your skin dry

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before the injection without fanning
or blowing on the clean area.

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Do not inject through clothes
and do not give an injection

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in an area of the skin that is tender,
bruised, red or hard.

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Hold the body of the pre-filled syringe
in one hand without touching the plunger.

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Pull the needle cover
straight off and discard it.

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Do not touch the needle
or let it touch anything.

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It's normal to see a drop of liquid
at the end of the needle.

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Hold the body

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of the pre-filled syringe with one hand
between the thumb and index finger.

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Do not pull back on
the plunger at any time.

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Do not use the
pre-filled syringe if it is dropped without the needle cover

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in place.

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Use the other hand to gently pinch
the cleaned area of the skin

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and hold firmly.

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Use a quick dart-like motion
to insert the needle

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into the pinched skin
at around a 45-degree angle.

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Inject all of the liquid by using your thumb
to push the plunger all the way in,

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until the pre-filled
syringe is empty.

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When the plunger is pushed
as far as it will go,

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keep pressure on the plunger head.

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Take the needle out of the skin
and let go of the skin.

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Slowly
take your thumb off the plunger head.

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The plunger will move up with your finger

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and retract the needle
into the needle guard.

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After completing the injection, press
a cotton ball or gauze pad

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on the skin at the injection site
without rubbing.

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Slight
bleeding at the injection site is normal.

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You may cover the injection site with
a small adhesive bandage, if necessary.

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If you need to give yourself
two injections,

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Choose two different sites
for these injections

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(for example, one injection
on the right hand side of the belly

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and the other injection on the left hand
side of the belly),

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and give the injections
one right after the other.

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On completion,

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put the used syringes in a puncture
resistant container like a sharps

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container straight away after use,
according to your local regulations.

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Do not dispose of loose syringes
in your household rubbish.

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Dispose of the antiseptic wipe, cotton bowl
or gauze pad and packaging

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in your household rubbish.

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Never re-use a syringe.